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methionine metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
S-adenosyl-L-methionine <=> H+ + nicotianamine + S-methyl-5''-thioadenosine 2.5.1.43 nicotianamine synthase

S-ribosylhomocysteine <=> L-homocysteine + (S)-4,5-dihydroxypentan-2,3-dione 4.4.1.21 S-ribosylhomocysteine lyase

L-homocysteine + betaine <=> L-methionine + N,N-dimethylglycine 2.1.1.5 betaine---homocysteine S-methyltransferase

5-(methylthio)-2,3-dioxopentyl_phosphate <=> H+ + 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl_phosphate 3.1.3.77 acireductone synthase
4.1.1.39 ribulose-bisphosphate carboxylase
4.2.1.11 phosphopyruvate hydratase
5.3.2.5 2,3-diketo-5-methylthiopentyl-1-phosphate enolase




S-methyl-5''-thioadenosine + phosphate <=> adenine + S-methyl-5-thio-alpha-D-ribose_1-phosphate 2.4.2.1 purine-nucleoside phosphorylase
2.4.2.28 S-methyl-5'-thioadenosine phosphorylase
3.2.2.9 adenosylhomocysteine nucleosidase



S-methyl-5''-thioadenosine + H2O <=> 5-methylthioribose + adenine 3.2.2.16 methylthioadenosine nucleosidase
3.2.2.9 adenosylhomocysteine nucleosidase


L-homoserine + succinyl-CoA <=> O-succinyl-L-homoserine + CoA 2.3.1.46 homoserine O-succinyltransferase

O-succinyl-L-homoserine + L-cysteine <=> L-cystathionine + succinate + H+ 2.5.1.48 cystathionine gamma-synthase

L-methionine + H2O <=> methanethiol + 2-oxobutyrate + NH3 4.4.1.11 methionine gamma-lyase

L-methionine + thioredoxin_disulfide + H2O <=> L-methionine_(R)-S-oxide + thioredoxin 1.8.4.11 peptide-methionine (S)-S-oxide reductase
1.8.4.12 peptide-methionine (R)-S-oxide reductase
1.8.4.14 L-methionine (R)-S-oxide reductase
1.8.4.B3




L-cysteine + O-phospho-L-homoserine <=> L-cystathionine + phosphate 2.5.1.48 cystathionine gamma-synthase

ATP + L-methionine + H2O <=> S-adenosyl-L-methionine + phosphate + diphosphate 2.5.1.6 methionine adenosyltransferase

S-adenosyl-L-methionine + L-homocysteine <=> L-methionine + S-adenosyl-L-homocysteine + H+ 2.1.1.10 homocysteine S-methyltransferase
2.1.1.13 methionine synthase
2.1.1.14 5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
2.1.1.280 selenocysteine Se-methyltransferase




L-cystathionine + H2O <=> L-homocysteine + pyruvate + NH3 2.5.1.48 cystathionine gamma-synthase
3.5.1.61 mimosinase
4.2.1.22 cystathionine beta-synthase
4.4.1.1 cystathionine gamma-lyase
4.4.1.13 cysteine-S-conjugate beta-lyase
4.4.1.28 L-cysteine desulfidase
4.4.1.3 dimethylpropiothetin dethiomethylase







ATP + 5-methylthioribose <=> H+ + ADP + S-methyl-5-thio-alpha-D-ribose_1-phosphate 2.7.1.100 S-methyl-5-thioribose kinase

elongator_tRNAMet + L-methionine + ATP <=> L-methionyl-[elongator_tRNAMet] + diphosphate + AMP 6.1.1.10 methionine---tRNA ligase

S-adenosyl-L-homocysteine + H2O <=> S-ribosylhomocysteine + adenine 3.2.2.16 methylthioadenosine nucleosidase
3.2.2.30 aminodeoxyfutalosine nucleosidase
3.2.2.9 adenosylhomocysteine nucleosidase



5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine <=> tetrahydropteroyl-Glu3 + L-methionine 2.1.1.13 methionine synthase
2.1.1.14 5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase


L-homocysteine + 5-methyltetrahydrofolate <=> L-methionine + tetrahydrofolate 2.1.1.13 methionine synthase
2.1.1.14 5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase


S-methyl-5-thio-D-ribulose_1-phosphate <=> 5-(methylthio)-2,3-dioxopentyl_phosphate + H2O 4.2.1.109 methylthioribulose 1-phosphate dehydratase

S-adenosyl-L-methionine + DNA <=> S-adenosyl-L-homocysteine + DNA_containing_5-methylcytosine 2.1.1.37 DNA (cytosine-5-)-methyltransferase

1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 <=> H+ + 4-methylsulfanyl-2-oxobutanoate + formate 1.13.11.54 acireductone dioxygenase [iron(II)-requiring]

L-methionine + H2O + O2 <=> 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2 1.13.12.9 phenylalanine 2-monooxygenase
1.4.3.2 L-amino-acid oxidase


2-hydroxy-5-(methylthio)-3-oxopent-1-enyl_phosphate + H2O <=> 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate 3.1.3.77 acireductone synthase
3.1.3.87 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase


S-adenosyl-L-methionine + H2O <=> adenosine + L-methionine + H+ 2.5.1.B21
3.13.1.8 S-adenosyl-L-methionine hydrolase (adenosine-forming)


S-adenosyl-L-homocysteine + H2O <=> L-homocysteine + adenosine 3.3.1.1 adenosylhomocysteinase

S-methyl-5-thio-alpha-D-ribose_1-phosphate <=> S-methyl-5-thio-D-ribulose_1-phosphate 5.3.1.23 S-methyl-5-thioribose-1-phosphate isomerase

S-adenosyl-L-methionine + H+ <=> CO2 + S-adenosylmethioninamine 4.1.1.19 arginine decarboxylase
4.1.1.50 adenosylmethionine decarboxylase


L-methionine + phenylpyruvate <=> 4-methylsulfanyl-2-oxobutanoate + L-phenylalanine 2.6.1.14 asparagine---oxo-acid transaminase
2.6.1.15 glutamine---pyruvate transaminase
2.6.1.28 tryptophan---phenylpyruvate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.51 serine---pyruvate transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.58 phenylalanine(histidine) transaminase
2.6.1.60 aromatic-amino-acid---glyoxylate transaminase
2.6.1.64 glutamine---phenylpyruvate transaminase
2.6.1.88 methionine transaminase










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